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Eldepryl

Generic name: selegiline (oral) [ se-LE-ji-leen ]
Brand names: Eldepryl, Zelapar
Drug classes: Dopaminergic antiparkinsonism agents, Monoamine oxidase inhibitors

Medically reviewed by Drugs.com. Last updated on Aug 23, 2023.

What is Eldepryl?

Eldepryl prevents the breakdown of a chemical in your brain called dopamine. Low levels of dopamine are associated with Parkinson's disease.

Eldepryl capsules are used together with levodopa and carbidopa to treat symptoms of Parkinson's disease.

Eldepryl may also be used for purposes not listed in this medication guide.

Warnings

Serious drug interactions can occur when certain medicines are used together with Eldepryl. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.

While taking Eldepryl, do not drink alcohol or eat foods that are high in tyramine, listed in the "What should I avoid while using Eldepryl?" section of this leaflet. Eating tyramine while you are using selegiline can raise your blood pressure to dangerous levels and cause life-threatening symptoms.

Do not stop taking Eldepryl suddenly or you may have harmful side effects. Keep taking the medicine as prescribed. Talk with your doctor before stopping the medication.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medication. Talk with your doctor if you believe you have any intense or unusual urges while taking Eldepryl.

Before taking this medicine

You should not use Eldepryl if you are allergic to selegiline, or if you have taken fluoxetine (Prozac, Sarafem and others) within the past 5 weeks.

Some medicines can cause unwanted or dangerous effects when used with Eldepryl. Your doctor may need to change your treatment plan if you use any of the following drugs:

After you stop taking Eldepryl, you must wait at least 14 days before taking any of the medications listed above.

To make sure Eldepryl is safe for you, tell your doctor if you have:

People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for.

It is not known whether Eldepryl will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether selegiline passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take Eldepryl?

Take Eldepryl exactly as it was prescribed for you. all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended. Do not change your doses or medication schedule without your doctor's advice.

Eldepryl capsules are usually taken twice a day, at breakfast and lunch. Follow your doctor's instructions.

While you are using Eldepryl and for 14 days after you stop, you must not eat foods listed in the "What should I avoid?" section of this leaflet. Eating these foods while you are using selegiline can raise your blood pressure to dangerous levels.

Foods that you MAY eat include:

Do not stop taking Eldepryl suddenly or you may have harmful side effects. For best results, keep taking the medicine as prescribed.

Store this medicine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe headache, hallucinations, vision problems, sweating, cool or clammy skin, fast or uneven heart rate, feeling light-headed, fainting, or seizure (convulsions).

What to avoid

Avoid drinking alcohol while you are taking Eldepryl.

While taking Eldepryl and for 14 days after you stop, you must NOT eat foods that are high in tyramine, including:

Eating tyramine while you are using selegiline can raise your blood pressure to dangerous levels which could cause life-threatening side effects. You should become very familiar with the list of foods to avoid while you are using Eldepryl.

Eldepryl may impair your thinking or reactions. Some people taking this medicine have fallen asleep during normal daytime activities such as working, talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. Be careful if you drive or do anything that requires you to be alert.

Eldepryl side effects

Get emergency medical help if you have signs of an allergic reaction to Eldepryl: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.

Common Eldepryl side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Eldepryl?

Many drugs can interact with selegiline, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Eldepryl. Give a list of all your medicines to any healthcare provider who treats you.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Eldepryl only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.